Category Our Technology

The HMFFE technology solution we use is based on a completely different and innovative technology path compared to traditional and Pro-A affinity high efficiency column chromatography. It is also very complementary to the traditional path.

HMFFE has obvious advantages in cost, efficiency and performance

HMFFE can act as the front-end/back-end process of Pro-A. It improves efficiency and reduces costs

HMFFE enables direct purification of BsAb

HMFFE can reduce the difficulty of designing antibodies

Antibody therapy that have failed in due to limitation of the purification process may be reconsidered

Solution Based on Microfluidic MEMS Chip and High-efficiency miniature continuous liquid phase electrophoresis (HMFFE)

• Stable pH in antibody environment 

• No denaturation conditions

• Precision micromachining

• Strict power and temperature management

• High-speed closed-loop feedback control which  eliminates the influence of environmental factors such as flow rate, viscosity, temperature and so on

• High-efficiency processing, each channel can reach 1~10uL per second (The capacity of 1,000 channels can reach 250kg@5g/L per year)

Affinity Chromatography

Fluctuation of pH value in the process increases the risk of charge variation

The ligands used in affinity chromatography are costly

Leakage of ligands

Relatively low productivity

Presents the limited lifetime

The desorption procedure results in partial denaturation of the bound protein

Mismatch of BsAb heterogeneous antibody brings technological and cost-related challenges

Requires the repeat process of capture-release-cleaning

The sample volume must be precisely adjusted while performing affinity chromatography